CovidSeniorV1, Main, Exploration, bibRecord, 000315

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection.

Identifieur interne : 000315 ( Main/Exploration ); précédent : 000314; suivant : 000316

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection.

Auteurs : Donogh Maguire [Royaume-Uni] ; Marylynne Woods [Royaume-Uni] ; Conor Richards [Royaume-Uni] ; Ross Dolan [Royaume-Uni] ; Jesse Wilson Veitch [Royaume-Uni] ; Wei M J. Sim [Royaume-Uni] ; Olivia E H. Kemmett [Royaume-Uni] ; David C. Milton [Royaume-Uni] ; Sophie L W. Randall [Royaume-Uni] ; Ly D. Bui [Royaume-Uni] ; Nicola Goldmann [Royaume-Uni] ; Allan Cameron [Royaume-Uni] ; Barry Laird [Royaume-Uni] ; Dinesh Talwar [Royaume-Uni] ; Ian Godber [Royaume-Uni] ; Alan Davidson [Royaume-Uni] ; Donald C. Mcmillan [Royaume-Uni]

Source :

Journal of translational medicine [ 1479-5876 ] ; 2020.

RBID : pubmed:32933530

Descripteurs français

English descriptors

KwdEn :
- Age Factors (MeSH), Aged (MeSH), Aged, 80 and over (MeSH), Betacoronavirus (MeSH), C-Reactive Protein (metabolism), Coronavirus Infections (epidemiology), Coronavirus Infections (mortality), Coronavirus Infections (physiopathology), Female (MeSH), Hospital Mortality (MeSH), Hospitalization (MeSH), Hospitals, Teaching (MeSH), Hospitals, Urban (MeSH), Humans (MeSH), Inflammation (physiopathology), Lymphocytes (MeSH), Male (MeSH), Middle Aged (MeSH), Multivariate Analysis (MeSH), Neutrophils (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (mortality), Pneumonia, Viral (physiopathology), Prognosis (MeSH), Scotland (epidemiology), Translational Medical Research (MeSH).
MESH :
- chemical , metabolism : C-Reactive Protein.
- geographic , epidemiology : Scotland.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- mortality : Coronavirus Infections, Pneumonia, Viral.
- physiopathology : Coronavirus Infections, Inflammation, Pneumonia, Viral.
- Age Factors, Aged, Aged, 80 and over, Betacoronavirus, Female, Hospital Mortality, Hospitalization, Hospitals, Teaching, Hospitals, Urban, Humans, Lymphocytes, Male, Middle Aged, Multivariate Analysis, Neutrophils, Pandemics, Prognosis, Translational Medical Research.

Abstract

BACKGROUND

Severe COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associated with the development of multiple organ failure.

METHODS

Electronic patient records for patients who were admitted to an urban teaching hospital during the initial 7-week period of the COVID-19 pandemic in Glasgow, U.K. (17th March 2020-1st May 2020) were examined for routine clinical, laboratory and clinical outcome data. Age, sex, BMI and documented evidence of COVID-19 infection at time of discharge or death certification were considered minimal criteria for inclusion.

RESULTS

Of the 224 patients who fulfilled the criteria for inclusion, 52 (23%) had died at 30-days following admission. COVID-19 related respiratory failure (75%) and multiorgan failure (12%) were the commonest causes of death recorded. Age ≥ 70 years (p < 0.001), past medical history of cognitive impairment (p ≤ 0.001), previous delirium (p < 0.001), clinical frailty score > 3 (p < 0.001), hypertension (p < 0.05), heart failure (p < 0.01), national early warning score (NEWS) > 4 (p < 0.01), positive CXR (p < 0.01), and subsequent positive COVID-19 swab (p ≤ 0.001) were associated with 30-day mortality. CRP > 80 mg/L (p < 0.05), albumin < 35 g/L (p < 0.05), peri-operative Glasgow Prognostic Score (poGPS) (p < 0.05), lymphocytes < 1.5 10

CONCLUSION

Age ≥ 70 years and severe systemic inflammation as measured by the peri-operative Glasgow Prognostic Score are independently associated with 30-day mortality among patients admitted to hospital with COVID-19 infection.

DOI: 10.1186/s12967-020-02524-4
PubMed: 32933530
PubMed Central: PMC7491021

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 000202
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Le document en format XML

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<author><name sortKey="Goldmann, Nicola" sort="Goldmann, Nicola" uniqKey="Goldmann N" first="Nicola" last="Goldmann">Nicola Goldmann</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Acute Medicine, Glasgow Royal Infirmary, Glasgow, G4 0SF</wicri:regionArea>
<wicri:noRegion>G4 0SF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Laird, Barry" sort="Laird, Barry" uniqKey="Laird B" first="Barry" last="Laird">Barry Laird</name>
<affiliation wicri:level="4"><nlm:affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU</wicri:regionArea>
<orgName type="university">Université d'Édimbourg</orgName>
<placeName><settlement type="city">Édimbourg</settlement>
<region type="country">Écosse</region>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:affiliation>St Columba's Hospice, 15 Boswall Rd, Edinburgh, EH5 3RW, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>St Columba's Hospice, 15 Boswall Rd, Edinburgh, EH5 3RW</wicri:regionArea>
<wicri:noRegion>EH5 3RW</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Talwar, Dinesh" sort="Talwar, Dinesh" uniqKey="Talwar D" first="Dinesh" last="Talwar">Dinesh Talwar</name>
<affiliation wicri:level="1"><nlm:affiliation>The Scottish Trace Element and Micronutrient Reference Laboratory, Department of Biochemistry, Royal Infirmary, Glasgow, G31 2ER, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The Scottish Trace Element and Micronutrient Reference Laboratory, Department of Biochemistry, Royal Infirmary, Glasgow, G31 2ER</wicri:regionArea>
<wicri:noRegion>G31 2ER</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Godber, Ian" sort="Godber, Ian" uniqKey="Godber I" first="Ian" last="Godber">Ian Godber</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Biochemistry, Queen Elizabeth University Hospital, Govan, Glasgow, G51 4TF, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Clinical Biochemistry, Queen Elizabeth University Hospital, Govan, Glasgow, G51 4TF</wicri:regionArea>
<wicri:noRegion>G51 4TF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Davidson, Alan" sort="Davidson, Alan" uniqKey="Davidson A" first="Alan" last="Davidson">Alan Davidson</name>
<affiliation wicri:level="1"><nlm:affiliation>Emergency Medicine Department, Glasgow Royal Infirmary, 84 Castle Street, Glasgow, G4 0SF, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Emergency Medicine Department, Glasgow Royal Infirmary, 84 Castle Street, Glasgow, G4 0SF</wicri:regionArea>
<wicri:noRegion>G4 0SF</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcmillan, Donald C" sort="Mcmillan, Donald C" uniqKey="Mcmillan D" first="Donald C" last="Mcmillan">Donald C. Mcmillan</name>
<affiliation wicri:level="4"><nlm:affiliation>Academic Unit of Surgery, School of Medicine, University of Glasgow, New Lister Building, Royal Infirmary, Glasgow, G31 2ER, UK.</nlm:affiliation>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Academic Unit of Surgery, School of Medicine, University of Glasgow, New Lister Building, Royal Infirmary, Glasgow, G31 2ER</wicri:regionArea>
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<placeName><settlement type="city">Glasgow</settlement>
<region type="country">Écosse</region>
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<series><title level="j">Journal of translational medicine</title>
<idno type="eISSN">1479-5876</idno>
<imprint><date when="2020" type="published">2020</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term>
<term>Aged (MeSH)</term>
<term>Aged, 80 and over (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>C-Reactive Protein (metabolism)</term>
<term>Coronavirus Infections (epidemiology)</term>
<term>Coronavirus Infections (mortality)</term>
<term>Coronavirus Infections (physiopathology)</term>
<term>Female (MeSH)</term>
<term>Hospital Mortality (MeSH)</term>
<term>Hospitalization (MeSH)</term>
<term>Hospitals, Teaching (MeSH)</term>
<term>Hospitals, Urban (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Inflammation (physiopathology)</term>
<term>Lymphocytes (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Multivariate Analysis (MeSH)</term>
<term>Neutrophils (MeSH)</term>
<term>Pandemics (MeSH)</term>
<term>Pneumonia, Viral (epidemiology)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (physiopathology)</term>
<term>Prognosis (MeSH)</term>
<term>Scotland (epidemiology)</term>
<term>Translational Medical Research (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse multifactorielle (MeSH)</term>
<term>Betacoronavirus (MeSH)</term>
<term>Facteurs âges (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>Granulocytes neutrophiles (MeSH)</term>
<term>Hospitalisation (MeSH)</term>
<term>Humains (MeSH)</term>
<term>Hôpitaux d'enseignement (MeSH)</term>
<term>Hôpitaux urbains (MeSH)</term>
<term>Infections à coronavirus (mortalité)</term>
<term>Infections à coronavirus (physiopathologie)</term>
<term>Infections à coronavirus (épidémiologie)</term>
<term>Inflammation (physiopathologie)</term>
<term>Lymphocytes (MeSH)</term>
<term>Mortalité hospitalière (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pandémies (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (physiopathologie)</term>
<term>Pneumopathie virale (épidémiologie)</term>
<term>Pronostic (MeSH)</term>
<term>Protéine C-réactive (métabolisme)</term>
<term>Recherche médicale translationnelle (MeSH)</term>
<term>Sujet âgé (MeSH)</term>
<term>Sujet âgé de 80 ans ou plus (MeSH)</term>
<term>Écosse (épidémiologie)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>C-Reactive Protein</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Scotland</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Coronavirus Infections</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Protéine C-réactive</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Inflammation</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Coronavirus Infections</term>
<term>Inflammation</term>
<term>Pneumonia, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term>
<term>Pneumopathie virale</term>
<term>Écosse</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Betacoronavirus</term>
<term>Female</term>
<term>Hospital Mortality</term>
<term>Hospitalization</term>
<term>Hospitals, Teaching</term>
<term>Hospitals, Urban</term>
<term>Humans</term>
<term>Lymphocytes</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multivariate Analysis</term>
<term>Neutrophils</term>
<term>Pandemics</term>
<term>Prognosis</term>
<term>Translational Medical Research</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte d'âge moyen</term>
<term>Analyse multifactorielle</term>
<term>Betacoronavirus</term>
<term>Facteurs âges</term>
<term>Femelle</term>
<term>Granulocytes neutrophiles</term>
<term>Hospitalisation</term>
<term>Humains</term>
<term>Hôpitaux d'enseignement</term>
<term>Hôpitaux urbains</term>
<term>Lymphocytes</term>
<term>Mortalité hospitalière</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Pronostic</term>
<term>Recherche médicale translationnelle</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
</keywords>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Severe COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associated with the development of multiple organ failure.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Electronic patient records for patients who were admitted to an urban teaching hospital during the initial 7-week period of the COVID-19 pandemic in Glasgow, U.K. (17th March 2020-1st May 2020) were examined for routine clinical, laboratory and clinical outcome data. Age, sex, BMI and documented evidence of COVID-19 infection at time of discharge or death certification were considered minimal criteria for inclusion.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Of the 224 patients who fulfilled the criteria for inclusion, 52 (23%) had died at 30-days following admission. COVID-19 related respiratory failure (75%) and multiorgan failure (12%) were the commonest causes of death recorded. Age ≥ 70 years (p < 0.001), past medical history of cognitive impairment (p ≤ 0.001), previous delirium (p < 0.001), clinical frailty score > 3 (p < 0.001), hypertension (p < 0.05), heart failure (p < 0.01), national early warning score (NEWS) > 4 (p < 0.01), positive CXR (p < 0.01), and subsequent positive COVID-19 swab (p ≤ 0.001) were associated with 30-day mortality. CRP > 80 mg/L (p < 0.05), albumin < 35 g/L (p < 0.05), peri-operative Glasgow Prognostic Score (poGPS) (p < 0.05), lymphocytes < 1.5 10</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Age ≥ 70 years and severe systemic inflammation as measured by the peri-operative Glasgow Prognostic Score are independently associated with 30-day mortality among patients admitted to hospital with COVID-19 infection.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">32933530</PMID>
<DateCompleted><Year>2020</Year>
<Month>10</Month>
<Day>02</Day>
</DateCompleted>
<DateRevised><Year>2020</Year>
<Month>10</Month>
<Day>02</Day>
</DateRevised>
<Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1479-5876</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>18</Volume>
<Issue>1</Issue>
<PubDate><Year>2020</Year>
<Month>09</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>Journal of translational medicine</Title>
<ISOAbbreviation>J Transl Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection.</ArticleTitle>
<Pagination><MedlinePgn>354</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1186/s12967-020-02524-4</ELocationID>
<Abstract><AbstractText Label="BACKGROUND">Severe COVID-19 infection results in a systemic inflammatory response (SIRS). This SIRS response shares similarities to the changes observed during the peri-operative period that are recognised to be associated with the development of multiple organ failure.</AbstractText>
<AbstractText Label="METHODS">Electronic patient records for patients who were admitted to an urban teaching hospital during the initial 7-week period of the COVID-19 pandemic in Glasgow, U.K. (17th March 2020-1st May 2020) were examined for routine clinical, laboratory and clinical outcome data. Age, sex, BMI and documented evidence of COVID-19 infection at time of discharge or death certification were considered minimal criteria for inclusion.</AbstractText>
<AbstractText Label="RESULTS">Of the 224 patients who fulfilled the criteria for inclusion, 52 (23%) had died at 30-days following admission. COVID-19 related respiratory failure (75%) and multiorgan failure (12%) were the commonest causes of death recorded. Age ≥ 70 years (p < 0.001), past medical history of cognitive impairment (p ≤ 0.001), previous delirium (p < 0.001), clinical frailty score > 3 (p < 0.001), hypertension (p < 0.05), heart failure (p < 0.01), national early warning score (NEWS) > 4 (p < 0.01), positive CXR (p < 0.01), and subsequent positive COVID-19 swab (p ≤ 0.001) were associated with 30-day mortality. CRP > 80 mg/L (p < 0.05), albumin < 35 g/L (p < 0.05), peri-operative Glasgow Prognostic Score (poGPS) (p < 0.05), lymphocytes < 1.5 10<sup>9</sup>
/l (p < 0.05), neutrophil lymphocyte ratio (p ≤ 0.001), haematocrit (< 0.40 L/L (male)/ < 0.37 L/L (female)) (p ≤ 0.01), urea > 7.5 mmol/L (p < 0.001), creatinine > 130 mmol/L (p < 0.05) and elevated urea: albumin ratio (< 0.001) were also associated with 30-day mortality. On multivariate analysis, age ≥ 70 years (O.R. 3.9, 95% C.I. 1.4-8.2, p < 0.001), past medical history of heart failure (O.R. 3.3, 95% C.I. 1.2-19.3, p < 0.05), NEWS > 4 (O.R. 2.4, 95% C.I. 1.1-4.4, p < 0.05), positive initial CXR (O.R. 0.4, 95% C.I. 0.2-0.9, p < 0.05) and poGPS (O.R. 2.3, 95% C.I. 1.1-4.4, p < 0.05) remained independently associated with 30-day mortality. Among those patients who tested PCR COVID-19 positive (n = 122), age ≥ 70 years (O.R. 4.7, 95% C.I. 2.0-11.3, p < 0.001), past medical history of heart failure (O.R. 4.4, 95% C.I. 1.2-20.5, p < 0.05) and poGPS (O.R. 2.4, 95% C.I. 1.1-5.1, p < 0.05) remained independently associated with 30-days mortality.</AbstractText>
<AbstractText Label="CONCLUSION">Age ≥ 70 years and severe systemic inflammation as measured by the peri-operative Glasgow Prognostic Score are independently associated with 30-day mortality among patients admitted to hospital with COVID-19 infection.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maguire</LastName>
<ForeName>Donogh</ForeName>
<Initials>D</Initials>
<Identifier Source="ORCID">0000-0002-0317-4079</Identifier>
<AffiliationInfo><Affiliation>Emergency Medicine Department, Glasgow Royal Infirmary, 84 Castle Street, Glasgow, G4 0SF, UK. Donogh.Maguire@glasgow.ac.uk.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Woods</LastName>
<ForeName>Marylynne</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Richards</LastName>
<ForeName>Conor</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Dolan</LastName>
<ForeName>Ross</ForeName>
<Initials>R</Initials>
<AffiliationInfo><Affiliation>Academic Unit of Surgery, School of Medicine, University of Glasgow, New Lister Building, Royal Infirmary, Glasgow, G31 2ER, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Veitch</LastName>
<ForeName>Jesse Wilson</ForeName>
<Initials>JW</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Sim</LastName>
<ForeName>Wei M J</ForeName>
<Initials>WMJ</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Kemmett</LastName>
<ForeName>Olivia E H</ForeName>
<Initials>OEH</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Milton</LastName>
<ForeName>David C</ForeName>
<Initials>DC</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Randall</LastName>
<ForeName>Sophie L W</ForeName>
<Initials>SLW</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bui</LastName>
<ForeName>Ly D</ForeName>
<Initials>LD</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Goldmann</LastName>
<ForeName>Nicola</ForeName>
<Initials>N</Initials>
<AffiliationInfo><Affiliation>School of Medicine Veterinary and Life Sciences, Wolfson Medical School Building, University of Glasgow, University Avenue, Glasgow, G12 8QQ, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Cameron</LastName>
<ForeName>Allan</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Department of Acute Medicine, Glasgow Royal Infirmary, Glasgow, G4 0SF, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Laird</LastName>
<ForeName>Barry</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, EH4 2XU, UK.</Affiliation>
</AffiliationInfo>
<AffiliationInfo><Affiliation>St Columba's Hospice, 15 Boswall Rd, Edinburgh, EH5 3RW, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Talwar</LastName>
<ForeName>Dinesh</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>The Scottish Trace Element and Micronutrient Reference Laboratory, Department of Biochemistry, Royal Infirmary, Glasgow, G31 2ER, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Godber</LastName>
<ForeName>Ian</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Biochemistry, Queen Elizabeth University Hospital, Govan, Glasgow, G51 4TF, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Davidson</LastName>
<ForeName>Alan</ForeName>
<Initials>A</Initials>
<AffiliationInfo><Affiliation>Emergency Medicine Department, Glasgow Royal Infirmary, 84 Castle Street, Glasgow, G4 0SF, UK.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>McMillan</LastName>
<ForeName>Donald C</ForeName>
<Initials>DC</Initials>
<AffiliationInfo><Affiliation>Academic Unit of Surgery, School of Medicine, University of Glasgow, New Lister Building, Royal Infirmary, Glasgow, G31 2ER, UK.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2020</Year>
<Month>09</Month>
<Day>15</Day>
</ArticleDate>
</Article>
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<MedlineTA>J Transl Med</MedlineTA>
<NlmUniqueID>101190741</NlmUniqueID>
<ISSNLinking>1479-5876</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>9007-41-4</RegistryNumber>
<NameOfSubstance UI="D002097">C-Reactive Protein</NameOfSubstance>
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</ChemicalList>
<SupplMeshList><SupplMeshName Type="Disease" UI="C000657245">COVID-19</SupplMeshName>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="Y">Betacoronavirus</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D002097" MajorTopicYN="N">C-Reactive Protein</DescriptorName>
<QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017052" MajorTopicYN="N">Hospital Mortality</DescriptorName>
</MeshHeading>
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</MeshHeading>
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</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D008214" MajorTopicYN="N">Lymphocytes</DescriptorName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D009504" MajorTopicYN="N">Neutrophils</DescriptorName>
</MeshHeading>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
<QualifierName UI="Q000401" MajorTopicYN="N">mortality</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011379" MajorTopicYN="N">Prognosis</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012606" MajorTopicYN="N" Type="Geographic">Scotland</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D057170" MajorTopicYN="N">Translational Medical Research</DescriptorName>
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	Serveur d'exploration sur la COVID chez les séniors
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Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection.

Prognostic factors in patients admitted to an urban teaching hospital with COVID-19 infection.

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